To Cite Sentieon® tools, please consider the corresponding pipeline publications listed below.

• [DNAscope for ONT Dataset - BioRxiv 2025] - Accelerated and High-Accuracy Variant Calling on Oxford Nanopore Technologies Sequencing Data with the Sentieon DNAscope LongRead and Hybrid Pipelines

• [DNAscope Hybrid - Frontiers in Bioinformatics 2025] - A Novel and Accelerated Method for Integrated Alignment and Variant Calling from Short and Long Reads

• [non-UMI ctDNA - BioRxiv 2024] - Optimizing Accuracy and Efficiency in Analyzing Non-UMI Liquid Biopsy Datasets Using the Sentieon ctDNA Pipeline

• [Gene Editing - JGG 2023] - CRISPR-detector: fast and accurate detection, visualization, and annotation of genome-wide mutations induced by genome editing events

• [DNAscope - BioRxiv 2022] - DNAscope: High accuracy small variant calling using machine learning

• [DNAscope LongRead - BioRxiv 2022] - Sentieon DNAscope LongRead – A highly Accurate, Fast, and Efficient Pipeline for Germline Variant Calling from PacBio HiFi reads

• [UMI - BioRxiv 2022] - Processing UMI Datasets at High Accuracy and Efficiency with the Sentieon ctDNA Analysis Pipeline

• [​TNscope - BioRxiv 2018] - TNscope: Accurate Detection of Somatic Mutations with Haplotype-based Variant Candidate Detection and Machine Learning Filtering

• ​[DNAseq/TNseq - BioRxiv 2017] - The Sentieon Genomics Tools - A fast and accurate solution to variant calling from next-generation sequence data

• [DNAseq - PeerJ 2016] - Sentieon DNA Pipeline for Variant Detection, Software-only solution, over 20X faster than GATK 3.3 with identical results

Selected Third Party Benchmark Publications:

• [DNAseq - Scientific Reports 2025] - Benchmarking of variant calling software for whole-exome sequencing using gold standard datasets
  

• [DNAscope - Research Square 2024] - Toward best practices for detecting germline small variants: a large-scale real-world WES benchmarking study using the Quartet DNA reference materials

• [DNAseq - MedRxiv 2024] - Rapid NGS Analysis on Google Cloud Platform: performance benchmark and user tutorial

• [DNAscope - BioRxiv 2022] - Sequencing by avidity enables high accuracy with low reagent consumption

• [DNAscope - BMC Genomics 2022] - Accuracy benchmark of the GeneMind GenoLab M sequencing platform for WGS and WES analysis

• [TNscope - Briefings in Bioinformatics 2020] - Benchmarking variant callers in next-generation and third-generation sequencing analysis

• [DNAscope - BioRxiv 2020] - Advanced Whole Genome Sequencing Using an Entirely PCR-free Massively Parallel Sequencing Workflow

• [DNAseq - Frontiers 2019] - Sentieon DNASeq Variant Calling Workflow Demonstrates Strong Computational Performance and Accuracy