Overview
Sentieon® provides complete solutions for DNA/RNA data with software that is deployable on any generic CPU-based computing system. Our software improves upon the BWA, STAR and Minimap2 aligners with accelerated alignment speeds while producing identical output. Germline and somatic SNV, Indel, SV, and CNV calling is supported from short and long read data with award-winning accuracy through the use of sequencing platform-specific model files. UMI consensus, large-scale joint calling, CRISPR analysis, quality control and BAM preprocessing are included through modular software components. Our products have been extensively tested and validated by customers, and have processed millions of samples totaling over 3000 petabases of sequence. You can find out how our customers are using the Sentieon® tools in the citations page.
-
Accelerated BWA/GATK Compliant Pipelines
Concordant with BWA-MEM, STAR, Minimap2, Picard and GATK for drop-in replacement, and 10x faster.
-
Compute Cost Reduction on Generic Hardware
Being deployed local or online, process a 30x WGS dataset in <30 minutes, at <2 USD compute costs.
-
Sequencer Agnostic and Highly Accurate
Winner of multiple precisionFDA Challenges, supporting mainstream sequencers with top accuracy.
Featured Pipeline - DNAscope
Sentieon DNAscope provides improved accuracy due to improved active region detection, more powerful local assembly of reads, and incorporation of pre-trained machine learning models for both short reads and long reads sequencers.
-
Published preprint demonstrating world-class accuracy;
Whole-genome 30x fastq to VCF within 30 mins;
Supports short and structural variant calling;
-
Co-authored appnote demonstrating world-class accuracy;
Whole-genome 30x fastq to VCF within 30 mins;
Supports short and structural variant calling;
-
Co-authored preprint demonstrating world-class accuracy;
Award-winning pipeline for SNP/Indel/SV detection;
Processing speed 6x faster than DeepVariant;
-
Co-announced benchmarks demonstrating world-class accuracy;
Customized pipeline and models;
Calling variants from 30x WGS within 22 mins;
-
Published manuscript demonstrating highest accuracy;
Optimized model available;
Whole-genome 30x fastq to VCF within 30 mins;
-
Optimized pipeline for SNP/Inde/SV detection;
Higher accuracy than Clair3 and Sniffles2;
DNAscope for ONT Pipeline is 3-5x faster;
-
Co-authored appnote demonstrating top accuracy;
DNAscope joint calling with non-Salus datasets;
Supports WGS and WES;
-
Combines short- and long-read data sequenced from the same sample;
Novel integrated alignment and variant calling pipeline;
Output SNP/Indel/SV/CNV from a single pipeline;
Efficiently complete analysis in 90 minutes;
Pipeline Functions
| Pipelines | DNAscope (short reads) | Pangenome | DNAscope LongRead | DNAscope Hybird | DNAseq | TNscope (somatic) | TNseq (somatic) |
| Alignment | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ |
| SNP/Indel | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ | ✔ |
| SV | ✔ | ✔ | ✔ | ✔ | ✔ | ||
| CNV | ✔ | ✔ | ✔ | ||||
| Segdup Genes | ✔ | ✔ | ✔ | ||||
| UMI Process | ✔ | ||||||
| Matching GATK | ✔ | ✔ | |||||
| • DNAscope (short reads) - DNAscope pipeline conducts short reads alignment, germline variant calling for SNP, Indel, SV, CNV, and Segdup. | |||||||
| • Pangenome - Pangenome pipeline conducts short reads alignment to graph reference genome, germline variant calling for SNP, Indel, SV, CNV, and Segdup. | |||||||
| • DNAscope LongRead - DNAscope LongRead pipeline conducts long reads alignment, germline variant calling for SNP, Indel, and SV. | |||||||
| • DNAscope Hybrid - DNAscope Hybrid pipeline conducts short and long reads alignment, germline variant calling for SNP, Indel, SV, CNV, and Segdup. | |||||||
| • DNAseq - DNAseq pipeline conducts short reads alignment, germline variant calling for SNP and Indel, matching GATK result. | |||||||
| • TNscope - TNscope pipeline conducts short reads alignment, UMI processing, somatic variant calling for SNP, Indel, and SV. | |||||||
| • TNseq - TNseq pipeline conducts short reads alignment, somatic variant calling for SNP and Indel, matching GATK result. |
Who We Serve
-
Genome Sequencing Service Providers
-
Molecular Diagnostic Companies
-
Pharmaceutical and Biotech Companies
-
Hospitals and Cancer Centers
-
Direct to Consumer Genomics Companies
-
Academic and Research Institutes